抗肿瘤药。551. 从紫羊蹄甲中分离得到鲍氏抑素1 - 4及其结构。

Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea.

作者信息

Pettit George R, Numata Atsushi, Iwamoto Chika, Usami Yoshihide, Yamada Takeshi, Ohishi Hirofumi, Cragg Gordon M

机构信息

Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, 85287-2404, USA.

出版信息

J Nat Prod. 2006 Mar;69(3):323-7. doi: 10.1021/np058075+.

DOI:10.1021/np058075+

PMID:16562827

Abstract

Bioassay-guided (P388 lymphocytic leukemia cell line) separation of extracts prepared from the leaves, stems, and pods of Bauhinia purpurea, and, in parallel, its roots, led to the isolation of four new dibenz[b,f]oxepins (2a, 3-5) named bauhiniastatins 1-4, as well as the known and related pacharin (1) as cancer cell growth inhibitors. The occurrence of oxepin derivatives in nature is quite rare. Bauhiniastatins 1-4 were found to exhibit significant growth inhibition against a minipanel of human cancer cell lines, and bauhiniastatin 1 (2a) was also found to inhibit the P388 cancer cell line. Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR.

摘要

采用生物测定法（P388淋巴细胞白血病细胞系）对紫羊蹄甲叶、茎、荚果及其根提取物进行分离，从中分离出4种新的二苯并[b,f]氧杂环庚三烯（2a、3 - 5），命名为bauhiniastatins 1 - 4，以及已知的相关化合物pacharin（1），它们均为癌细胞生长抑制剂。氧杂环庚三烯衍生物在自然界中十分罕见。研究发现，bauhiniastatins 1 - 4对一小部分人类癌细胞系具有显著的生长抑制作用，且bauhiniastatin 1（2a）对P388癌细胞系也有抑制作用。通过包括高分辨质谱（HRMS）和二维核磁共振（2D NMR）在内的光谱技术确定了这些新型癌细胞生长抑制剂的结构。