用于生物系统和医学的二苯并[o]氧杂卓分子。

Dibenzo[]oxepine Molecules Used in Biological Systems and Medicine.

机构信息

Department of Organic Chemistry, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.

出版信息

Int J Mol Sci. 2023 Jul 27;24(15):12066. doi: 10.3390/ijms241512066.

In this short review, including 113 references, issues related to dibenzo[]oxepine derivatives are presented. Dibenzo[]oxepine scaffold is an important framework in medicinal chemistry, and its derivatives occur in several medicinally relevant plants. At the same time, the structure, production, and therapeutic effects of dibenzo[]oxepines have not been extensively discussed thus far and are presented in this review. This manuscript addresses the following issues: extracting dibenzo[]oxepines from plants and its significance in medicine, the biosynthesis of dibenzo[]oxepines, the active synthetic dibenzo[]oxepine derivatives, the potential of dibenzo[]oxepines as microtubule inhibitors, and perspective for applications of dibenzo[]oxepine derivatives. In conclusion, this review describes studies on various structural features and pharmacological actions of dibenzo[]oxepine derivatives.

在这篇简短的综述中，包括 113 篇参考文献，呈现了与二苯并[B,D]氧杂卓衍生物相关的问题。二苯并[B,D]氧杂卓支架是药物化学中的一个重要框架，其衍生物存在于几种具有药用价值的植物中。同时，到目前为止，二苯并[B,D]氧杂卓的结构、生产和治疗效果尚未得到广泛讨论，本综述对此进行了介绍。本文讨论了以下问题：从植物中提取二苯并[B,D]氧杂卓及其在医学上的意义、二苯并[B,D]氧杂卓的生物合成、活性合成的二苯并[B,D]氧杂卓衍生物、二苯并[B,D]氧杂卓作为微管抑制剂的潜力，以及二苯并[B,D]氧杂卓衍生物的应用前景。总之，本综述描述了对二苯并[B,D]氧杂卓衍生物的各种结构特征和药理作用的研究。