西尔维苷，一种来自林地鼠麴草的二萜糖苷衍生物。

Sylviside, a diterpene glucoside derivative from Gnaphalium sylvaticum.

作者信息

Konopleva Mira M, Matławska Irena, Wojcińska Małgorzata, Ahmed Ahmed A, Rybczyńska Maria, Paszel Anna, Ohta Shinji, Hirata Toshifumi, Bylka Wiesława, Mabry Tom J, Cannon John F

机构信息

Department of Pharmacognosy and Botany, Vitebsk State University, Republic of Belarus.

出版信息

J Nat Prod. 2006 Mar;69(3):394-6. doi: 10.1021/np050144x.

DOI:10.1021/np050144x

PMID:16562842

Abstract

A new diterpene glucoside (1), named sylviside, was isolated from the aerial parts of Gnaphalium sylvaticum. Its structure was elucidated as 2beta,15alpha,20alpha-trihydroxy-19,20-dicarboxy-ent-kaur-16-ene 2beta-O-(2'-angelate)-beta-D-glucopyranoside, on the basis of spectroscopic analysis ((1)H NMR, (13)C NMR, HMQC, HMBC, NOESY), and was confirmed by X-ray crystallographic analysis. Sylviside (1) displayed weak cytotoxicity against HeLa WT (human epitheloid cervical carcinoma) cells and was also evaluated for its effects on reversing multidrug resistance in HeLa cells overexpressing MDR1.

摘要

从林地鼠麴草的地上部分分离出一种新的二萜糖苷（1），命名为林地苷。基于光谱分析（1H NMR、13C NMR、HMQC、HMBC、NOESY），其结构被鉴定为2β,15α,20α-三羟基-19,20-二羧基-对映-贝壳杉-16-烯2β-O-(2'-当归酸)-β-D-葡萄糖吡喃糖苷，并通过X射线晶体学分析得到证实。林地苷（1）对HeLa WT（人上皮样宫颈癌）细胞显示出较弱的细胞毒性，并且还评估了其对逆转过表达MDR1的HeLa细胞中多药耐药性的影响。