来自 Croton laevigatus 的内酯型贝壳杉烷二萜。

Lactonecembranoids from Croton laevigatus.

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.

出版信息

J Nat Prod. 2010 Apr 23;73(4):792-5. doi: 10.1021/np100044t.

DOI:10.1021/np100044t

PMID:20307086

Abstract

Six new cembranoids, laevigatlactones A-F (1-6), and the known compound neocrotocembraneic acid (7) were isolated from leaves of Croton laevigatus. Their structures were elucidated on the basis of spectroscopic analysis, and that of 1 was confirmed by X-ray crystallography. Compound 2 exhibited modest cytotoxicity against HeLa cells, with an IC(50) value of 38.4 microM.

摘要

从 Croton laevigatus 的叶子中分离得到了六个新的海松烷二萜，分别为 laevigatlactones A-F（1-6）和已知化合物 neocrotocembraneic acid（7）。基于光谱分析确定了它们的结构，并且通过 X 射线晶体学确定了 1 的结构。化合物 2 对 HeLa 细胞表现出适度的细胞毒性，IC₅₀值为 38.4 μM。