Shiian D N
Vopr Onkol. 1975;21(2):34-40.
Eighty one patients were studied for individual susceptibility of gastric tumors to 5-FU as evidenced by endogenic respiration and glycolysis of fresh tumor sections, the main criterion being the suppressed respiration, the accessory one inhibition of glycolysis. Three groups of tumors were differentiated: susceptible (25.9%), slightly susceptible (28.4%) and unsusceptible (45.7%) to 5-fluoruracil. Mostly adenocarcinomas were found in a group of susceptible tumors, scirrhous and colloid cancers -- in an unsusceptible group. A correlation outlined between the results of determining susceptibility in vitro and clinical data enabled to recommend the method of determining susceptibility to 5-FU for clinical application.
通过新鲜肿瘤切片的内源性呼吸和糖酵解来研究81例患者胃肿瘤对5-氟尿嘧啶（5-FU）的个体易感性，主要标准是呼吸抑制，次要标准是糖酵解抑制。区分出三组肿瘤：对5-氟尿嘧啶敏感（25.9%）、轻度敏感（28.4%）和不敏感（45.7%）。在敏感肿瘤组中大多发现腺癌，在不敏感组中发现硬癌和胶样癌。体外易感性测定结果与临床数据之间呈现的相关性使得推荐5-FU易感性测定方法用于临床应用成为可能。
