甲氧苄啶-磺胺甲恶唑诱发的超敏反应综合征中的人疱疹病毒6型脑炎
[Human herpesvirus 6 encephalitis in trimethoprim-sulfamethoxazole-induced hypersensitivity syndrome].
作者信息
Mohammedi I, Mausservey C, Hot A, Najioullah F, Kanitakis J, Robert D
机构信息
Service de réanimation médicale, Pavillon N, hôpital Edouard-Herriot, place d'Arsonval, 69003 Lyon, France.
出版信息
Rev Med Interne. 2006 Jun;27(6):499-501. doi: 10.1016/j.revmed.2006.01.018. Epub 2006 Mar 3.
INTRODUCTION
Human herpesvirus 6 (HHV-6), the causative agent of the common exanthem subitum, is a known cause of central nervous system infection in immunocompromised patients. It has been suggested that HHV-6 participate in the development of drug-induced hypersensitivity syndrome.
CASE REPORT
We reported a case of HHV-6 encephalitis associated with hypersensitivity syndrome induced by trimethoprim-sulfamethoxazole in a 72-year-old HIV-negative woman.
DISCUSSION
Our case confirmed that reactivation of HHV-6 infection may contribute to the development of the hypersensitivity syndrome.
引言
人类疱疹病毒6型（HHV - 6）是幼儿急疹的病原体，也是免疫功能低下患者中枢神经系统感染的已知病因。有人提出HHV - 6参与药物性超敏反应综合征的发生发展。
病例报告
我们报告了一例72岁HIV阴性女性因甲氧苄啶 - 磺胺甲恶唑诱发超敏反应综合征合并HHV - 6脑炎的病例。
讨论
我们的病例证实HHV - 6感染的重新激活可能促成超敏反应综合征的发生。
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