Dudai Yadin
Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Curr Opin Neurobiol. 2006 Apr;16(2):174-8. doi: 10.1016/j.conb.2006.03.010. Epub 2006 Mar 24.
Ample evidence suggests that upon their retrieval, items in long-term memory enter a transient special state, in which they might become prone to change. The process that generates this state is dubbed 'reconsolidation'. The dominant conceptual framework in this revitalized field of memory research focuses on whether reconsolidation resembles consolidation, which is the process that converts an unstable short-term memory trace into a more stable long-term trace. However, this emphasis on the comparison of reconsolidation to consolidation deserves reassessment. Instead, the phenomenon of reconsolidation, irrespective of its relevance to consolidation, provides a unique opportunity to tap into the molecular, cellular and circuit correlates of memory persistence and retrieval, of which we currently know only little.
大量证据表明,长期记忆中的项目在被提取时会进入一种短暂的特殊状态,在这种状态下它们可能易于发生变化。产生这种状态的过程被称为“重新巩固”。在这个记忆研究的复兴领域中,占主导地位的概念框架关注的是重新巩固是否类似于巩固,巩固是将不稳定的短期记忆痕迹转化为更稳定的长期痕迹的过程。然而,这种对重新巩固与巩固进行比较的强调值得重新评估。相反,重新巩固现象,无论其与巩固的相关性如何,都提供了一个独特的机会来探究记忆持久性和提取的分子、细胞和神经回路相关性,而我们目前对此知之甚少。