McDonagh D, Vollmer R T, Shelburne J D
Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Mod Pathol. 1991 Jul;4(4):436-40.
We examined the ultrastructure of 76 lung cancers and counted the number of intercellular junctions per area of tissue section. The total number of desmosomes, intermediate junctions, and tight junctions ranged from zero to 300 per 0.157 cm2 of tissue section area, and each type of carcinoma showed a considerable range in concentration of intercellular junctions. Multivariate analysis showed that the number of junctions was significantly tied to the probability of the patient's having extensive stage and to survival time, even after accounting for the routine light microscopic diagnosis of small cell versus non-small cell carcinoma. These results suggest that a tumor's ability to spread and metastasize is inversely related to its number of intercellular junctions, and this conclusion appears to apply to both small cell and non-small cell carcinomas.
我们检查了76例肺癌的超微结构，并计算了组织切片单位面积内细胞间连接的数量。在每0.157平方厘米的组织切片面积中，桥粒、中间连接和紧密连接的总数从零到300不等，且每种类型的癌在细胞间连接的浓度上都有相当大的范围。多变量分析表明，即使在考虑了小细胞癌与非小细胞癌的常规光学显微镜诊断之后，连接数量仍与患者处于广泛期的概率以及生存时间显著相关。这些结果表明，肿瘤的扩散和转移能力与其细胞间连接的数量呈负相关，这一结论似乎适用于小细胞癌和非小细胞癌。
