Bhombal Shazia, Bothwell Marcella R, Bauer S M
Department of Otolaryngology, University of Missouri-Columbia School of Medicine, 65212, USA.
Otolaryngol Head Neck Surg. 2006 Apr;134(4):578-80. doi: 10.1016/j.otohns.2005.11.041.
Food allergies in childhood have been found to vary in frequency from 6% to 8% in the general population. Previous studies indicate milk allergy affects approximately 2.5% of infants and egg allergy has been estimated at 1.6% to 2.6%. Numerous allergists believe that the prevalence of food allergies is rising, similar to the rise in other atopic conditions. Prior studies have demonstrated that food-specific IgE is a useful test for diagnosing symptomatic allergies to certain foods, including milk and eggs, and could decrease the need to perform cumbersome multiple double-blind, placebo-controlled food challenges in children based on history alone. The purpose of this study was to determine the prevalence of food allergies and elevated IgE in a consecutive series of pediatric otolaryngology patients.
ImmunoCap studies were drawn in a 2-year series of children undergoing ENT procedures of bilateral myringotomy with tubes (BMT) with or without adenoidectomy or tonsillectomy or adenoidectomy alone between 2001 and 2003. Sera was analyzed for increased total IgE antibodies, as well as specific IgE antibodies to antigens, including milk, egg, beef, and environmental allergens. A positive patient history or family history of allergy were documented.
A total of 242 patients were assessed. Of the study population, milk allergy was found in 10.7%; egg white allergy was found in 5.0%. The prevalence of elevated IgE among participants was 11.2%. The overall food allergy prevalence was 14.5%.
Although we cannot imply causality, the study demonstrated an increased prevalence of food allergy in children undergoing ENT procedures, specifically milk and eggs, than in previous population studies.
C-4.
在普通人群中，儿童食物过敏的发生率在6%至8%之间。先前的研究表明，牛奶过敏影响约2.5%的婴儿，鸡蛋过敏的估计发生率为1.6%至2.6%。众多过敏症专科医生认为，食物过敏的患病率正在上升，与其他特应性疾病的上升情况相似。先前的研究已证明，食物特异性IgE是诊断对某些食物（包括牛奶和鸡蛋）的症状性过敏的一项有用检测，并且可以减少仅根据病史就对儿童进行繁琐的多次双盲、安慰剂对照食物激发试验的必要性。本研究的目的是确定一系列连续的儿科耳鼻喉科患者中食物过敏和IgE升高的患病率。
在2001年至2003年期间，对一系列连续两年接受双侧鼓膜切开置管术（BMT）的儿童进行了ImmunoCap检测，这些儿童还接受了或未接受腺样体切除术或扁桃体切除术，或仅接受腺样体切除术。分析血清中总IgE抗体以及针对包括牛奶、鸡蛋、牛肉和环境过敏原在内的抗原的特异性IgE抗体。记录了患者的过敏阳性病史或家族史。
共评估了242名患者。在研究人群中，发现牛奶过敏的占10.7%；蛋清过敏的占5.0%。参与者中IgE升高的患病率为11.2%。总体食物过敏患病率为14.5%。
虽然我们不能推断因果关系，但该研究表明，接受耳鼻喉科手术的儿童中食物过敏的患病率，特别是牛奶和鸡蛋过敏的患病率，高于先前的人群研究。
C-4。
