Dainer P M
Department of Medicine, School of Medicine, East Carolina University, Greenville, NC.
South Med J. 1991 Oct;84(10):1250-4. doi: 10.1097/00007611-199110000-00021.
I have reported a rare case of hypercalcemia associated with small cell carcinoma of the lung. Our patient initially had small cell carcinoma of the right bronchial orifice, with metastases to the mediastinum and the lumbar vertebrae. Complete remission was achieved with chemotherapy over the next 3 years, but then three metastatic foci were found in the brain. Subsequently, recurrent small cell carcinoma was identified in the lung, and chemotherapy was resumed. The patient's condition deteriorated over the following 2 months. When intravenous saline failed to control hypercalcemia, octreotide acetate was given. The serum calcium level returned to normal and remained stable, without any other intervention, until the day after octreotide therapy was discontinued. I have discussed hypercalcemia due to bronchogenic carcinoma in terms of incidence in relation to histologic type, mechanisms of pathogenesis, and current treatment methods.
我曾报告过一例与肺小细胞癌相关的罕见高钙血症病例。我们的患者最初患有右支气管口小细胞癌，并伴有纵隔和腰椎转移。在接下来的3年里，通过化疗实现了完全缓解，但随后在脑部发现了3个转移灶。随后，在肺部发现复发性小细胞癌，并恢复了化疗。在接下来的2个月里，患者的病情恶化。当静脉输注生理盐水未能控制高钙血症时，给予了醋酸奥曲肽。血清钙水平恢复正常并保持稳定，在没有任何其他干预的情况下，一直维持到奥曲肽治疗停止后的第二天。我已经从与组织学类型相关的发病率、发病机制和当前治疗方法等方面讨论了支气管源性癌所致的高钙血症。
