氮氧化物的免疫调节和抗菌作用。
Immunoregulatory and antimicrobial effects of nitrogen oxides.
作者信息
Mannick Joan B
机构信息
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
出版信息
Proc Am Thorac Soc. 2006 Apr;3(2):161-5. doi: 10.1513/pats.200505-048BG.
Abstract
The therapeutic effects of inhaled nitric oxide (NO) therapy are thought to be restricted to the pulmonary vasculature because of rapid inactivation of NO by hemoglobin in the bloodstream. However, recent data suggest that inhaled NO may not only be scavenged by the heme iron of hemoglobin but also may react with protein thiols in the bloodstream, including cysteine-93 of the hemoglobin B subunit. Reaction of NO with protein or peptide thiols is termed S-nitrosylation and results in the formation of relatively stable protein S-nitrosothiols that carry NO bioactivity to distal organs. Thus, inhaled NO-induced protein S-nitrosylation may allow inhaled NO to have multiple as yet undiscovered physiologic and pathophysiologic effects outside of the lung. Here we review the immunoregulatory and antimicrobial functions of NO and the potential effects of inhaled NO therapy on host defense.
摘要
吸入一氧化氮（NO）疗法的治疗效果被认为仅限于肺血管系统，因为血液中的血红蛋白会使NO迅速失活。然而，最近的数据表明，吸入的NO不仅可能被血红蛋白的血红素铁清除，还可能与血液中的蛋白质硫醇反应，包括血红蛋白B亚基的半胱氨酸-93。NO与蛋白质或肽硫醇的反应被称为S-亚硝基化，会导致形成相对稳定的蛋白质S-亚硝基硫醇，这些硫醇将NO生物活性传递到远端器官。因此，吸入NO诱导的蛋白质S-亚硝基化可能使吸入的NO在肺外产生多种尚未被发现的生理和病理生理效应。在此，我们综述了NO的免疫调节和抗菌功能以及吸入NO疗法对宿主防御的潜在影响。
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