Suh Jeong Ill
Department of Internal Medicine, College of Medicine, Dongguk University, Gyeongju, Korea.
Korean J Hepatol. 2006 Mar;12(1):5-15.
Cholestatic liver diseases are characterized by impairments of bile flows and accumulations of biliary constituents such as bile acids and bilirubin. The changes of phase I and II metabolism and the hepatobiliary transport system minimize cholestatic liver injury. These adaptive responses are transcriptionally regulated by several nuclear receptors. Recent studies have revealed that the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are key nuclear receptors for regulating many of the adaptive responses noted in cholestasis. PXR and CAR coordinately regulate not only bile acid metabolism and transport, but also bilirubin clearance. PXR and CAR ligands may be useful in the future for the treatment of cholestatic liver disease.
胆汁淤积性肝病的特征是胆汁流动受损以及胆汁成分如胆汁酸和胆红素的蓄积。I相和II相代谢以及肝胆转运系统的变化可将胆汁淤积性肝损伤降至最低。这些适应性反应受几种核受体的转录调控。最近的研究表明，孕烷X受体（PXR）和组成型雄甾烷受体（CAR）是调节胆汁淤积中许多适应性反应的关键核受体。PXR和CAR不仅协同调节胆汁酸代谢和转运，还调节胆红素清除。PXR和CAR配体未来可能对胆汁淤积性肝病的治疗有用。
