Varis Asta, Salmela Anna-Leena, Kallio Marko J
Cancer Biology and Cell Screening Department, VTT Medical Biotechnology, Itäinen Pitkäkatu 4A, 20521, Turku, Finland.
Chromosoma. 2006 Aug;115(4):288-95. doi: 10.1007/s00412-005-0046-0. Epub 2006 Mar 25.
Cenp-F (mitosin) is a large coiled-coil protein whose function has remained obscure since its identification a decade ago. It has been suggested that the protein plays a role in the kinetochore-mediated mitotic functions but until recently there was little evidence to support this postulation. Recent results from five laboratories have given insights on how Cenp-F may participate in the regulation of cell division. In this mini-review, we will summarize the current data regarding the mitotic tasks of Cenp-F as well as discuss how it is used as a proliferation marker of malignant cell growth in the clinic. Also, the protein's post-translational modification by farnesylation and potential contribution to cell cycle effects of farnesyl transferase inhibitors will be addressed.
着丝粒蛋白F（纺锤体丝蛋白）是一种大型卷曲螺旋蛋白，自十年前被发现以来，其功能一直不明。有人认为该蛋白在动粒介导的有丝分裂功能中发挥作用，但直到最近，几乎没有证据支持这一假设。来自五个实验室的最新结果揭示了着丝粒蛋白F可能如何参与细胞分裂的调控。在这篇小型综述中，我们将总结关于着丝粒蛋白F有丝分裂任务的当前数据，并讨论它如何在临床上用作恶性细胞生长的增殖标志物。此外，还将探讨该蛋白经法尼基化的翻译后修饰以及法尼基转移酶抑制剂对细胞周期效应的潜在影响。
