Hurst Daniel, Cedrone Nona
Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307, USA.
J Child Neurol. 2006 Feb;21(2):112-4. doi: 10.1177/08830738060210021801.
Two patients with spastic cerebral palsy recently treated with modafinil at the Walter Reed Army Medical Center child neurology clinic have stopped drooling. This occurred after starting modafinil for spasticity and without other changes in the patients' treatment programs. The decrease in drooling is to a remarkable degree. Both patients had a chronic problem with drooling. One patient has gone from wearing a bib or bandanna, which was constantly wet from drooling to being essentially dry. After starting modafinil, both patients stopped drooling. The parents initially observed decreased drooling at home. Clinic appointment examinations and evaluations at physical therapy confirmed these observations. Better coordination and speech have been noted in each patient. Modafinil improves drooling in at least some patients with spastic cerebral palsy. The decreased drooling is due to improvements noted in swallowing.
最近在沃尔特·里德陆军医疗中心儿童神经科诊所接受莫达非尼治疗的两名痉挛型脑瘫患者不再流口水。这是在开始使用莫达非尼治疗痉挛后出现的，且患者的治疗方案没有其他变化。流口水的减少程度显著。两名患者都有长期流口水的问题。一名患者过去一直戴着围嘴或头巾，由于流口水一直是湿的，现在基本上干了。开始使用莫达非尼后，两名患者都不再流口水。家长最初在家中观察到流口水减少。物理治疗门诊预约检查和评估证实了这些观察结果。在每名患者身上都注意到协调性和言语能力有所改善。莫达非尼至少在一些痉挛型脑瘫患者中改善了流口水的情况。流口水减少是由于吞咽功能有所改善。
