Vazquez Vincent, Penit-Soria Jacqueline, Durand Claudette, Besson Marie-Jo, Giros Bruno, Daugé Valérie
INSERM, U513, Créteil, F-94010 France; Université Paris XII, Créteil, F-94010 France.
Behav Brain Res. 2006 Jun 30;170(2):211-8. doi: 10.1016/j.bbr.2006.02.022. Epub 2006 Mar 29.
Short early manipulations of rodent postnatal environment may trigger long-term effects on neurobiological and behavioural phenotypes in adulthood. However, little is known about such effects of handling on the vulnerability to develop drug dependence. The present study aimed to analyze the long-term effects of a brief handling (1 min) on morphine and ethanol dependence and on the preproenkephalin (PPE) mRNA and mu opioid receptor levels. Handled rats showed a significant increase in morphine (25mg/l) but not ethanol (10%) consumption and preference after 7 weeks and no difference in morphine (2 and 5mg/kg) conditioned place preference. No difference of preproenkephalin mRNA and mu opioid receptor levels was detected in the mesolimbic system between both groups. These data emphasize that human brief handling, which can lead to morphine dependence development, constitutes in itself an experimental treatment and not a control condition.
对啮齿动物出生后早期环境进行短期操控，可能会对成年期的神经生物学和行为表型产生长期影响。然而，对于这种处理方式对药物依赖易感性的影响，人们了解甚少。本研究旨在分析短暂处理（1分钟）对吗啡和乙醇依赖以及前脑啡肽原（PPE）mRNA和μ阿片受体水平的长期影响。经过处理的大鼠在7周后吗啡（25mg/l）的消耗量和偏好显著增加，但乙醇（10%）的消耗量和偏好没有增加，并且在吗啡（2和5mg/kg）条件性位置偏爱方面没有差异。两组之间的中脑边缘系统中未检测到前脑啡肽原mRNA和μ阿片受体水平的差异。这些数据强调，人类的短暂处理本身构成一种实验性治疗，而非对照条件，因为它可能导致吗啡依赖的发展。
