King J A, Davila-Garcia M, Azmitia E C, Strand F L
Department of Biology, New York University, New York 10003.
Int J Dev Neurosci. 1991;9(3):281-6. doi: 10.1016/0736-5748(91)90048-q.
These studies were designed to examine the differential effects of prenatal or postnatal administration of ACTH 1-39 and nicotine, on 5-HT high affinity uptake in brainstem and hippocampal synaptosomes. ACTH was administered prenatally (to pregnant dams) and postnatally to the neonates. Postnatal administration of ACTH significantly increased high-affinity 5-HT uptake in the hippocampus and especially the brainstem at both 7 and 21 days after birth. Prenatal ACTH, on the other hand, transiently increased 5-HT uptake in only the brainstem at 7 days, a change that was reversed at 21 days. While the effects of postnatal nicotine administration were essentially the same as those of postnatal ACTH treatment, prenatal nicotine, unlike ACTH, did not alter 5-HT uptake in 7-day-old rats but did reduce uptake in both tissues at 21 days. The observation that postnatal nicotine mimics the effects of postnatal ACTH and that nicotine stimulates ACTH release, suggests that the postnatal effects of nicotine may be exerted through ACTH.
这些研究旨在考察产前或产后给予促肾上腺皮质激素1 - 39（ACTH 1 - 39）和尼古丁对脑干及海马突触体中5 - 羟色胺（5 - HT）高亲和力摄取的不同影响。促肾上腺皮质激素在产前（给予怀孕母鼠）和产后给予新生幼鼠。产后给予促肾上腺皮质激素显著增加了出生后7天和21天时海马尤其是脑干中5 - HT的高亲和力摄取。另一方面，产前给予促肾上腺皮质激素仅在出生后7天时短暂增加了脑干中5 - HT的摄取，这种变化在21天时逆转。虽然产后给予尼古丁的效果与产后促肾上腺皮质激素治疗的效果基本相同，但与促肾上腺皮质激素不同的是，产前尼古丁在7日龄大鼠中未改变5 - HT的摄取，但在21天时确实降低了两个组织中的摄取。产后尼古丁模拟产后促肾上腺皮质激素的作用以及尼古丁刺激促肾上腺皮质激素释放这一观察结果表明，尼古丁的产后作用可能是通过促肾上腺皮质激素发挥的。
