Schuck Sebastian, Simons Kai
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
J Cell Biol. 2006 Mar 27;172(7):963-5. doi: 10.1083/jcb.200603015.
The model that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) take a direct transport route to the apical membrane of epithelial cells has recently been challenged. In this issue, Paladino et al. (p. 1023) and Hua et al. (p. 1035) show that the original view nevertheless holds. This closes a chapter in the winding story of GPI-AP trafficking but opens another phase, as the controversy has stimulated the development of new methodology.
糖基磷脂酰肌醇（GPI）锚定蛋白（GPI-APs）直接运输至上皮细胞顶端膜的模型最近受到了挑战。在本期杂志中，帕拉迪诺等人（第1023页）和华等人（第1035页）表明，原来的观点仍然成立。这为GPI-AP转运这个曲折故事的一个篇章画上了句号，但同时开启了另一个阶段，因为这场争论推动了新方法的发展。
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