mTOR is out of control in polycystic kidney disease.
作者信息
Mostov Keith E
机构信息
Department of Anatomy, School of Medicine, University of California-San Francisco, Genentech Hall Room N212B, Box 2140, 600 16th Street, San Francisco, CA 94147, USA.
出版信息
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5247-8. doi: 10.1073/pnas.0601352103. Epub 2006 Mar 27.
Abstract
摘要
相似文献
1
mTOR is out of control in polycystic kidney disease.在多囊肾病中，mTOR失去控制。
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5247-8. doi: 10.1073/pnas.0601352103. Epub 2006 Mar 27.
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本文引用的文献
1
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.mTOR信号通路受多囊蛋白-1调控，抑制该通路可逆转多囊肾病中的肾囊肿形成。
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5466-71. doi: 10.1073/pnas.0509694103. Epub 2006 Mar 27.
2
Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease.多囊蛋白-1、信号转导和转录激活因子6（STAT6）以及P100在一条传导纤毛机械感觉并在多囊肾病中被激活的信号通路中发挥作用。
Dev Cell. 2006 Jan;10(1):57-69. doi: 10.1016/j.devcel.2005.12.005.
3
Rapamycin: an anti-cancer immunosuppressant?雷帕霉素：一种抗癌免疫抑制剂？
Crit Rev Oncol Hematol. 2005 Oct;56(1):47-60. doi: 10.1016/j.critrevonc.2004.09.009.
4
Dysregulation of the TSC-mTOR pathway in human disease.人类疾病中TSC-mTOR通路的失调。
Nat Genet. 2005 Jan;37(1):19-24. doi: 10.1038/ng1494.
5
Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.鞭毛内运输与纤毛相关的肾脏疾病：多囊肾病的纤毛假说
J Am Soc Nephrol. 2004 Oct;15(10):2528-36. doi: 10.1097/01.ASN.0000141055.57643.E0.
6
Cystic kidney diseases: all roads lead to the cilium.
Physiology (Bethesda). 2004 Aug;19:225-30. doi: 10.1152/physiol.00003.2004.
7
TSC2: filling the GAP in the mTOR signaling pathway.结节性硬化症复合物2（TSC2）：填补mTOR信号通路中的空白
Trends Biochem Sci. 2004 Jan;29(1):32-8. doi: 10.1016/j.tibs.2003.11.007.
8
Autosomal dominant polycystic kidney disease.常染色体显性多囊肾病
Nefrologia. 2003;23 Suppl 1:14-22.
9
Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.常染色体显性多囊肾病：分子遗传学与病理生理学
J Lab Clin Med. 2003 Feb;141(2):91-101. doi: 10.1067/mlc.2003.13.
10
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells.多囊蛋白1和2介导肾细胞初级纤毛中的机械感觉。
Nat Genet. 2003 Feb;33(2):129-37. doi: 10.1038/ng1076. Epub 2003 Jan 6.
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