戒酒的酒精依赖患者脑脊液中促甲状腺激素释放激素（TRH）浓度与TRH刺激后促甲状腺激素（TSH）反应之间的负相关关系。
Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients.
作者信息
Adinoff B, Nemeroff C B, Bissette G, Martin P R, Linnoila M
机构信息
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.
出版信息
Am J Psychiatry. 1991 Nov;148(11):1586-8. doi: 10.1176/ajp.148.11.1586.
The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.
作者对13名戒酒的酒精依赖患者进行了促甲状腺激素释放激素（TRH）刺激试验，并测量了脑脊液中TRH的浓度。他们发现促甲状腺激素（TSH）对TRH的反应与内源性脑脊液TRH浓度呈负相关。这一发现支持了以下假设：随着脑脊液TRH浓度的增加，垂体前叶TRH受体密度降低，导致TSH对TRH刺激的反应减弱。
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