Resino Salvador, Alvaro-Meca Alejandro, de José Maria Isabel, Martin-Fontelos Pablo, Gutiérrez Maria Dolores Gurbindo, Léon Juan Antonio, Ramos José Tomás, Ciria Luis, Muñoz-Fernández Maria Angeles
Laboratorio de Inmuno-Biología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Pediatr Infect Dis J. 2006 Apr;25(4):365-8. doi: 10.1097/01.inf.0000207419.50016.5e.
We conducted a retrospective study to analyze the CD4 recovery of naive vertically human immunodeficiency virus-infected children with severe immunodeficiency who were followed up during at least 4 years of receiving highly active antiretroviral therapy (HAART). Children with baseline CD4 of <15% did not reach a mean CD4 of > or =25% after the 4th year on HAART. We conclude that starting HAART after severe immunosuppression of naive HIV-infected children may not be effective for recovery of normal %CD4.
我们进行了一项回顾性研究，以分析在接受高效抗逆转录病毒治疗（HAART）至少4年期间接受随访的初治垂直感染人类免疫缺陷病毒且患有严重免疫缺陷的儿童的CD4恢复情况。基线CD4<15%的儿童在接受HAART治疗4年后未达到平均CD4≥25%。我们得出结论，初治HIV感染儿童在严重免疫抑制后开始HAART治疗可能对恢复正常的CD4百分比无效。
