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本文引用的文献
1
Activity and stability of yeast alcohol dehydrogenase (YADH) entrapped in aerosol OT reverse micelles.
Biotechnol Bioeng. 1992 Feb 20;39(4):474-8. doi: 10.1002/bit.260390416.
2
Synthesis, characterization and development of a high-throughput methodology for the discovery of botulinum neurotoxin a inhibitors.
J Comb Chem. 2006 Jul-Aug;8(4):513-21. doi: 10.1021/cc060010h.
3
Botulinal neurotoxins: revival of an old killer.
Curr Opin Pharmacol. 2005 Jun;5(3):274-9. doi: 10.1016/j.coph.2004.12.006.
4
Clostridium botulinum: a bug with beauty and weapon.
Crit Rev Microbiol. 2005;31(1):11-8. doi: 10.1080/10408410590912952.
5
The evolving field of biodefence: therapeutic developments and diagnostics.
Nat Rev Drug Discov. 2005 Apr;4(4):281-97. doi: 10.1038/nrd1694.
6
Activation, inhibition, and destabilization of Thermomyces lanuginosus lipase by detergents.
Biochemistry. 2005 Feb 8;44(5):1719-30. doi: 10.1021/bi0479757.
7
Substrate recognition strategy for botulinum neurotoxin serotype A.
Nature. 2004 Dec 16;432(7019):925-9. doi: 10.1038/nature03123. Epub 2004 Dec 12.
8
Identification of the major steps in botulinum toxin action.
Annu Rev Pharmacol Toxicol. 2004;44:167-93. doi: 10.1146/annurev.pharmtox.44.101802.121554.
9
Superactivity and conformational changes on alpha-chymotrypsin upon interfacial binding to cationic micelles.
Biochem J. 2004 Mar 15;378(Pt 3):1059-66. doi: 10.1042/BJ20031536.
10
Toxins as weapons of mass destruction. A comparison and contrast with biological-warfare and chemical-warfare agents.
Clin Lab Med. 2001 Sep;21(3):593-605.
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