利奈唑胺治疗严重感染时临床疗效良好，但不良反应发生率高：一项针对复杂患者监测治疗的拟议方案
Good clinical outcomes but high rates of adverse reactions during linezolid therapy for serious infections: a proposed protocol for monitoring therapy in complex patients.
作者信息
Bishop Emma, Melvani Sharmila, Howden Benjamin P, Charles Patrick G P, Grayson M Lindsay
机构信息
Infectious Diseases Department, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia.
出版信息
Antimicrob Agents Chemother. 2006 Apr;50(4):1599-602. doi: 10.1128/AAC.50.4.1599-1602.2006.
Abstract
We assessed the toxicity and clinical outcomes associated with linezolid therapy (mean duration, 29+/-28 days; range, 8 to 185 days) in 44 patients with serious gram-positive infections. Although a clinical cure was achieved in 73% of the cases, 28/44 (64%) had adverse reactions (thrombocytopenia, n=13; anemia, n=7; gastrointestinal, n=12; peripheral neuropathy, n=1; serotonin syndrome, n=1), such that a systematic monitoring protocol was developed.
摘要
我们评估了44例严重革兰氏阳性菌感染患者接受利奈唑胺治疗（平均疗程为29±28天；范围为8至185天）的毒性及临床结局。尽管73%的病例实现了临床治愈，但28/44（64%）的患者出现了不良反应（血小板减少症，n = 13；贫血，n = 7；胃肠道反应，n = 12；周围神经病变，n = 1；血清素综合征，n = 1），因此制定了系统的监测方案。
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