Asawa Koichiro, Kataoka Toru, Kobayashi Yoshiki, Hasegawa Takao, Nishioka Hiroki, Yamashita Hajime, Qiu Zhaohui, Ehara Shoichi, Hirose Makoto, Kamimori Kimio, Shimada Kenei, Yoshiyama Minoru, Yoshikawa Junichi
Department of Internal Medicine and Cardiology, Osaka City University Medical School, Asahimachi 1-4-3, Abeno-ku, Osaka 545-8585.
J Cardiol. 2006 Mar;47(3):133-41.
Optical coherence tomography(OCT)is a high-resolution imaging method that can clearly visualize vessels through the displacement of blood with flushing agents. Continuous imaging methods have not been established. This study investigated optimal methods for continuous OCT imaging.
Thirty-four arteries with stent implantation (24 peripheral and 10 coronary arteries)in 14 pigs were examined using OCT with a motorized pullback device. Two imaging methods (flush alone by liquid substance and flush with occlusion) were compared. Adequate image acquisition was defined as the entire circumferential intimal layer being detectable within continuous segments. To investigate factors that could influence image quality, stented regions were divided into 4-5 mm segments.
The flush with occlusion method provided better OCT images compared to flush alone (flush with occlusion: 60.9%, flush alone: 8.7%, p = 0.0002). Using the flush with occlusion method, the rate of adequate image acquisition was 64.4% and visualization of > 75% intimal circumference was 83.5%. Intravascular ultrasound could detect all stented regions. Segmental analyses found more adequate images were detected in smaller vessels (adequate segment: 3.8 +/- 0.4 mm, inadequate segment: 4.2 +/- 0.8 mm, p < 0.0001) or with centered image wire position (adequate segment: center 35%, inadequate segment: center 14%, p = 0.003). In addition, side branches did not affect image quality.
To acquire continuous OCT images, the flush with occlusion method was more effective compared to flush alone. Moreover, image quality is affected by vessel size and imaging wire position. These results suggest that optimized OCT imaging can provide continuous vessel detection.
光学相干断层扫描（OCT）是一种高分辨率成像方法，可通过使用冲洗剂使血液移位来清晰地可视化血管。尚未建立连续成像方法。本研究探讨了连续OCT成像的最佳方法。
使用带有电动回撤装置的OCT对14头猪体内的34条植入支架的动脉（24条外周动脉和10条冠状动脉）进行检查。比较了两种成像方法（仅用液体物质冲洗和闭塞冲洗）。将连续节段内整个圆周内膜层均可检测到定义为充分的图像采集。为了研究可能影响图像质量的因素，将支架置入区域分为4-5毫米的节段。
与仅冲洗相比，闭塞冲洗方法提供了更好的OCT图像（闭塞冲洗：60.9%，仅冲洗：8.7%，p = 0.0002）。使用闭塞冲洗方法时，充分图像采集率为64.4%，内膜圆周可视化>75%的比例为83.5%。血管内超声可检测到所有支架置入区域。节段分析发现，在较小血管（充分节段：3.8±0.4毫米，不充分节段：4.2±0.8毫米，p<0.0001）或成像导丝位置居中（充分节段：居中35%，不充分节段：居中14%，p = 0.003）时检测到的充分图像更多。此外，侧支不影响图像质量。
为了获取连续的OCT图像，闭塞冲洗方法比仅冲洗更有效。此外，图像质量受血管大小和成像导丝位置的影响。这些结果表明，优化的OCT成像可提供连续的血管检测。
