Kaidbey K H, Kligman A M
Arch Dermatol. 1977 May;113(5):592-5.
Coal tars of different origin were compared with regard to their capacity to cause a phototoxic reaction in human skin. The photosensitizing potencies were found to differ. Tars that were partially refined had less activity than crude coal tar. An extract of tar, liquor carbonis detergens, was the least photosensitizing. The phototoxic reaction to coal tar was found to be a two-stage process, an immediate wheal associated with sharp burning, followed by a raised, red, infiltrated lesion peaking at 24 to 48 hours. The phototoxic reaction was completely prevented when arterial blood flow was cut off. The histological findings were prominently epidermal, with strong intracellular edema sometimes leading to microvesicles. It seems a possibility that assaying phototoxic potentiality may provide a convenient measure of therapeutic efficacy of materials derived from coal tar.
对不同来源的煤焦油在引起人体皮肤光毒性反应的能力方面进行了比较。发现其光敏效力有所不同。部分精炼的焦油活性低于粗煤焦油。焦油提取物——煤焦油溶液的光敏性最低。发现煤焦油引起的光毒性反应是一个两阶段过程，先是伴有剧烈灼痛的即刻风团，随后是在24至48小时达到高峰的隆起、发红、浸润性损害。当切断动脉血流时，光毒性反应可完全避免。组织学检查结果主要在表皮，有时会出现强烈的细胞内水肿，进而导致微泡形成。测定光毒性潜力似乎有可能为源自煤焦油的材料的治疗效果提供一种便捷的衡量方法。
