Pittelkow M R, Perry H O, Muller S A, Maughan W Z, O'Brien P C
Arch Dermatol. 1981 Aug;117(8):465-8.
For many years, crude coal tar has been used for the treatment of psoriasis. The possible carcinogenic effect of crude coal tar and ultraviolet (UV) radiation (Goeckerman regimen), considered individually or in combination, has been of some concern to physicians. A 25-year follow-up study was completed on 280 patients with psoriasis who were hospitalized and treated with crude coal tar and UV radiation at the Mayo Clinic, Rochester, Minn, during the years 1950 through 1954. The results of this study suggest that the incidence of skin cancer is not appreciably increased above the expected incidence for the general population when patients are treated with coal tar ointments. It seems that the Goeckerman regimen (topical crude coal tar combined with UV radiation) can be used with minimal risk for skin cancer in the treatment of psoriasis.
多年来，粗煤焦油一直用于治疗银屑病。粗煤焦油和紫外线（UV）辐射（Goeckerman疗法）单独或联合使用时可能的致癌作用，一直是医生们关注的问题。对1950年至1954年期间在明尼苏达州罗切斯特市梅奥诊所住院并接受粗煤焦油和紫外线辐射治疗的280例银屑病患者进行了一项为期25年的随访研究。这项研究的结果表明，当患者使用煤焦油软膏治疗时，皮肤癌的发病率并未明显高于普通人群的预期发病率。看来，Goeckerman疗法（外用粗煤焦油联合紫外线辐射）在治疗银屑病时导致皮肤癌的风险极小。
