Luo Yun, Hu Yongzhou
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Arch Pharm (Weinheim). 2006 May;339(5):262-6. doi: 10.1002/ardp.200500227.
A series of novel antifungal triazole derivatives 2-aryl-1,2,4-triazolo[1,5-a]pyridine 9a-m were synthesized and tested in vitro for their growth inhibitory activities against C. albicans and T. rubrum. The MIC values indicate that the activities of three compounds were superior or comparable to fluconazole against both tested fungi, worthy of further investigation of its antifungal activities.
合成了一系列新型抗真菌三唑衍生物2-芳基-1,2,4-三唑并[1,5-a]吡啶9a-m，并对其体外抗白色念珠菌和红色毛癣菌的生长抑制活性进行了测试。最低抑菌浓度值表明，三种化合物对两种受试真菌的活性优于或相当于氟康唑，值得进一步研究其抗真菌活性。
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