孕妇哮喘与先兆子痫风险：一项病例对照研究。

Maternal asthma and risk of preeclampsia: a case-control study.

作者信息

Rudra Carole B, Williams Michelle A, Frederick Ihunnaya O, Luthy David A

机构信息

Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA.

出版信息

J Reprod Med. 2006 Feb;51(2):94-100.

PMID:16572909

Abstract

OBJECTIVE

To quantify the associations between asthma characteristics and the risk of preeclampsia.

STUDY DESIGN

In this case-control study, asthma history among 286 preeclampsia cases and 470 normotensive controls in Seattle was assessed by postpartum interview and medical record abstraction. OR and 95% CI were estimated using logistic regression. The sample size was adequate to detect unadjusted asthma history with ORs of > or =1.6 at a power of 80%.

RESULTS

After adjustment, women with a history of prepregnancy asthma diagnosis were not at increased preeclampsia risk (OR 0.94, 95% CI 0.58-1.52). Women experiencing asthma symptoms during pregnancy were more likely than pregnant nonasthmatics to have preeclampsia (OR 2.20, 95% CI 0.79-6.10). Those with long-term pre-pregnancy asthma and symptoms during pregnancy were at particularly increased risk (OR 9.09, 95% CI 1.02-81.6). Point estimates were generally higher after restriction to women withfull-term deliveries.

CONCLUSION

This analysis suggests that asthmatics, particularly those who are symptomatic during pregnancy, may be at higher risk of developing preeclampsia.

摘要

目的

量化哮喘特征与子痫前期风险之间的关联。

研究设计

在这项病例对照研究中，通过产后访谈和病历摘要评估了西雅图286例子痫前期病例和470例血压正常对照者的哮喘病史。使用逻辑回归估计比值比（OR）和95%置信区间（CI）。样本量足以检测未调整的哮喘病史，其OR值≥1.6，检验效能为80%。

结果

调整后，有孕前哮喘诊断史的女性子痫前期风险并未增加（OR 0.94，95%CI 0.58 - 1.52）。孕期出现哮喘症状的女性比未患哮喘的孕妇更易患子痫前期（OR 2.20，95%CI 0.79 - 6.10）。那些孕前有长期哮喘且孕期有症状的女性风险尤其增加（OR 9.09，95%CI 1.02 - 81.6）。在限制为足月分娩的女性后，点估计值通常更高。