Zhang Yong, Sun Shiwei, Wu Tao, Wang Jie, Liu Changning, Chen Lan, Zhu Xiaopeng, Zhao Yi, Zhang Zhihua, Shi Baochen, Lu Hongchao, Chen Runsheng
Bioinformatics Laboratory and National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Biochem Biophys Res Commun. 2006 May 12;343(3):950-5. doi: 10.1016/j.bbrc.2006.02.196. Epub 2006 Mar 20.
The Hfq-binding small RNAs (sRNAs) have recently drawn much attention as regulators of translation in Escherichia coli. We attempt to identify the targets of this class of sRNAs in genome scale and gain further insight into the complexity of translational regulation induced by Hfq-binding sRNAs. Using a new alignment algorithm, most known negatively regulated targets of Hfq-binding sRNAs were identified. The results also show several interesting aspects of the regulatory function of Hfq-binding sRNAs.
作为大肠杆菌中翻译的调节因子，与Hfq结合的小RNA（sRNA）近来备受关注。我们试图在基因组规模上鉴定这类sRNA的靶标，并进一步深入了解由与Hfq结合的sRNA诱导的翻译调控的复杂性。使用一种新的比对算法，鉴定出了大多数已知的受Hfq结合sRNA负调控的靶标。结果还显示了与Hfq结合的sRNA调控功能的几个有趣方面。
