小非编码RNA的多靶点调控在转录后水平上重塑基因表达。
Multiple target regulation by small noncoding RNAs rewires gene expression at the post-transcriptional level.
作者信息
Papenfort Kai, Vogel Jörg
机构信息
Max Planck Institute for Infection Biology, RNA Biology Group, Charitéplatz 1, 10117 Berlin, Germany.
出版信息
Res Microbiol. 2009 May;160(4):278-87. doi: 10.1016/j.resmic.2009.03.004. Epub 2009 Apr 12.
PMID:19366629
Abstract
Small noncoding RNAs (sRNAs), often in conjunction with Hfq protein, have increasingly been shown to regulate multiple rather than individual mRNAs, thereby reprogramming gene expression at the post-transcriptional level. This review summarizes how and when several such regulators (CyaR, DsrA, GcvB, OmrAB, RNAIII, RybB, RyhB) act upon multiple targets.
摘要
小非编码RNA（sRNA）通常与Hfq蛋白协同作用，越来越多的研究表明，它可调控多个而非单个mRNA，从而在转录后水平对基因表达进行重编程。本综述总结了几种此类调控因子（CyaR、DsrA、GcvB、OmrAB、RNAIII、RybB、RyhB）作用于多个靶标的方式和时间。
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