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GenRGenS:用于生成随机基因组序列和结构的软件。

GenRGenS: software for generating random genomic sequences and structures.

作者信息

Ponty Yann, Termier Michel, Denise Alain

机构信息

LRI, UMR CNRS 8623, Université Paris-Sud 11 F91405 Orsay cedex, France.

出版信息

Bioinformatics. 2006 Jun 15;22(12):1534-5. doi: 10.1093/bioinformatics/btl113. Epub 2006 Mar 30.

Abstract

GenRGenS is a software tool dedicated to randomly generating genomic sequences and structures. It handles several classes of models useful for sequence analysis, such as Markov chains, hidden Markov models, weighted context-free grammars, regular expressions and PROSITE expressions. GenRGenS is the only program that can handle weighted context-free grammars, thus allowing the user to model and to generate structured objects (such as RNA secondary structures) of any given desired size. GenRGenS also allows the user to combine several of these different models at the same time.

摘要

GenRGenS是一款专门用于随机生成基因组序列和结构的软件工具。它处理几类对序列分析有用的模型,如马尔可夫链、隐马尔可夫模型、加权上下文无关文法、正则表达式和PROSITE表达式。GenRGenS是唯一能够处理加权上下文无关文法的程序,从而允许用户对任何给定所需大小的结构化对象(如RNA二级结构)进行建模和生成。GenRGenS还允许用户同时组合几种不同的模型。

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