Perini P, Ranzato F, Calabrese M, Battistin L, Gallo P
Multiple Sclerosis Centre of the Veneto Region, Department of Neurosciences, University Hospital of Padova, Padova, Italy.
J Neurol Neurosurg Psychiatry. 2006 Aug;77(8):953-5. doi: 10.1136/jnnp.2005.086116. Epub 2006 Mar 30.
The intrathecal synthesis of IgM, determined at clinical onset in patients with multiple sclerosis, was found to correlate with the degree of disability (as evaluated by means of the Expanded Disability Status Scale) reached 15 years later (p<0.001). Moreover, a significant inverse correlation was observed between the value of the IgM index and time to the first relapse (p<0.001) and the initiation of the progressive phase of the disease (p = 0.01). The prognostic value of IgM in the CSF is confirmed in previous reports as well as by our study. If these findings are confirmed in patients with multiple sclerosis in a larger series, a helpful biological marker for selecting patients for immunomodulatory treatments will be available to neurologists.
在多发性硬化症患者临床发病时测定的鞘内IgM合成,发现与15年后达到的残疾程度(通过扩展残疾状态量表评估)相关(p<0.001)。此外,观察到IgM指数值与首次复发时间(p<0.001)和疾病进展期开始时间(p = 0.01)之间存在显著负相关。脑脊液中IgM的预后价值在先前的报告以及我们的研究中均得到证实。如果这些发现在更大系列的多发性硬化症患者中得到证实,神经科医生将可获得一种有助于选择免疫调节治疗患者的生物学标志物。