Sellebjerg F, Christiansen M, Garred P
MS Clinic Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Mult Scler. 1998 Jun;4(3):127-31. doi: 10.1177/135245859800400307.
Intrathecal immunoglobulin synthesis and activation of the complement cascade occurs in patients with multiple sclerosis (MS). The present study aimed at further studying the relation between intrathecal immunoglobulin synthesis and complement activation. We compared total intrathecal synthesis of IgA, IgG, and IgM, the number of cells secreting anti-myelin basic protein (MBP) and anti-proteolipid protein (PLP) antibodies of the IgG isotype and intrathecal activation of the complement cascade in patients with possible onset symptoms of MS (n = 18) or clinically definite MS (n = 30). Early activation of the complement cascade correlated with intrathecal synthesis of IgM. Intrathecal IgG, IgA and IgM synthesis also correlated weakly with the presence of cells secreting anti-MBP or anti-PLP autoantibodies. Full activation of the complement cascade did not correlate with any measures of intrathecal antibody synthesis. These findings suggest a complex relation between different immunoglobulin isotypes and complement activation which may have similarly complex roles in the pathogenesis of MS.
多发性硬化症（MS）患者存在鞘内免疫球蛋白合成及补体级联反应激活的情况。本研究旨在进一步探究鞘内免疫球蛋白合成与补体激活之间的关系。我们比较了可能出现MS发病症状的患者（n = 18）或临床确诊MS患者（n = 30）鞘内IgA、IgG和IgM的总合成量、分泌IgG同种型抗髓鞘碱性蛋白（MBP）和抗蛋白脂蛋白（PLP）抗体的细胞数量以及鞘内补体级联反应的激活情况。补体级联反应的早期激活与鞘内IgM的合成相关。鞘内IgG、IgA和IgM的合成与分泌抗MBP或抗PLP自身抗体的细胞的存在也存在较弱的相关性。补体级联反应的完全激活与鞘内抗体合成的任何指标均无相关性。这些发现表明不同免疫球蛋白同种型与补体激活之间存在复杂的关系，这在MS的发病机制中可能具有同样复杂的作用。
