Chigladze T T, Zhvaniia M A, Bekua M V
Georgian Med News. 2006 Feb(131):62-5.
The Osteogenesis imperfecta (OI) is a hereditary disturbance of collagen biosynthesis. The illness is characterized by frequent fractures that consequently cause functional disturbance of locomotion system as well as deformation of long tubular bones. The purpose of the present work was to study radiological features of clinical forms of osteogenesis imperfecta during bisphosphonate treatment in children according to the schemes we developed taking into consideration the type of illness and the age of the patient. The total number of 32 patients, aged 1-15, suffering from osteogenesis imperfecta, have been investigated. The patients have been divided into three groups depending on the type of illness (I, III and IV type). Type II (lethal form) has not been observed by us. All patients, participating in the study underwent radiological examination of tubular bones and vertebra pre and post treatment. The results of the study showed that bisphosphonate treatment has positive effects in patients of type I and IV of osteogenesis imperfecta and is less effective in the type III of the diseases.
成骨不全症（OI）是一种胶原蛋白生物合成的遗传性紊乱疾病。该疾病的特征是频繁骨折，进而导致运动系统功能障碍以及长管状骨变形。本研究的目的是根据我们制定的方案，考虑疾病类型和患者年龄，研究儿童成骨不全症临床类型在双膦酸盐治疗期间的放射学特征。对32例年龄在1至15岁的成骨不全症患者进行了调查。根据疾病类型（I型、III型和IV型）将患者分为三组。我们未观察到II型（致死型）。所有参与研究的患者在治疗前后均接受了管状骨和脊椎的放射学检查。研究结果表明，双膦酸盐治疗对I型和IV型成骨不全症患者有积极效果，而对III型疾病的效果较差。
