一种新型肌肉松弛剂（AH8165）对神经肌肉传递的作用。
Actions of a new muscle relaxant (AH8165) on neuromuscular transmission.
作者信息
Post E L, Sokoll M D, Gergis S D, Dretchen K L, Cronnelly R, Long J P
出版信息
Anesthesiology. 1975 Mar;42(3):240-4. doi: 10.1097/00000542-197503000-00003.
The effects of a new muscle relaxant, AH8165, on miniature endplate potential (MEPP) amplitude and frequency, endplate sensitivity to acetylcholine, and muscle twitch tension were studied in vitro in the frog sartorius muscle. Nerve terminal effects were studied in vivo in the cat soleus muscle and its ventral root fibers. AH8165 stimulates the nerve terminal, as evidenced by increased MEPP frequency and the appearance of post-drug repetitive activity. In the same concentration range at which MEPP frequency is increased, MEPP amplitude, endplate sensitivity to acetylcholine, and twitch tension are decreased. This suggests that AH8165 produces muscle relaxation by blocking postsynaptic cholinergic receptors. (Key works: Neuromuscular relaxants, AH8165.).
在青蛙缝匠肌上进行体外实验，研究了一种新型肌肉松弛剂AH8165对微小终板电位（MEPP）幅度和频率、终板对乙酰胆碱的敏感性以及肌肉抽搐张力的影响。在猫比目鱼肌及其腹根纤维上进行体内实验，研究了AH8165对神经末梢的作用。AH8165刺激神经末梢，表现为MEPP频率增加以及用药后出现重复活动。在MEPP频率增加的相同浓度范围内，MEPP幅度、终板对乙酰胆碱的敏感性以及抽搐张力均降低。这表明AH8165通过阻断突触后胆碱能受体产生肌肉松弛作用。（关键词：神经肌肉松弛剂，AH8165。）
Zotero 插件