1,2 - 二甲基 - 3 - 甲氧基羰基 - 4 - (2 - 硝基 - 4,5 - 二甲氧基苯基)吡咯对仓鼠抗利什曼原虫作用的超微结构研究
Ultrastructural study on the antileishmanial effect of 1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole in hamsters.
作者信息
Bhatnagar S, Maitra S C, Guru P Y, Katiyar J C
机构信息
Division of Parasitology, Central Drug Research Institute, Lucknow.
出版信息
Indian J Med Res. 1991 May;93:147-51.
An ultrastructure study was carried out on the effect of a standard drug sodium stibogluconate and a newly identified active CDRI compound 87/305 [1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole] on amastigotes of Leishmania donovani in macrophage cells of spleen of infected hamsters. While Na-stibogluconate exerted its effect by activating the digestion capacity of host macrophages, compound 87/305 was directly lethal to the parasites without, exerting any effect on the host cells.
对标准药物葡糖酸锑钠和新鉴定的活性CDRI化合物87/305 [1,2 - 二甲基 - 3 - 甲氧基羰基 - 4 - (2 - 硝基 - 4,5 - 二甲氧基苯基)吡咯]对感染仓鼠脾脏巨噬细胞内杜氏利什曼原虫无鞭毛体的影响进行了超微结构研究。葡糖酸锑钠通过激活宿主巨噬细胞的消化能力发挥作用，而化合物87/305对寄生虫具有直接致死作用，对宿主细胞无任何影响。
Zotero 插件