非免疫性无胸腺BALB/c小鼠的牙龈卟啉单胞菌实验性感染
Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice.
作者信息
Chen P B, Davern L B, Aguirre A
机构信息
Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo 14214.
出版信息
Infect Immun. 1991 Dec;59(12):4706-9. doi: 10.1128/iai.59.12.4706-4709.1991.
The purpose of this report was to study the role of T lymphocytes following injection of Porphyromonas gingivalis in a mouse abscess model. Three invasive P. gingivalis isolates (ATCC 53977, W83, and AJW4) were injected into athymic BALB/c mice and their heterozygous (nu/+) littermates. The athymic BALB/c (nu/nu) mice were able to localize the invasive P. gingivalis isolates at the injection site. By comparison, the heterozygous BALB/c (nu/+) littermates developed hemorrhagic secondary lesions within 24 h after subcutaneous injection of the same invasive P. gingivalis isolates. These results suggest that naive T lymphocytes may contribute to the pathology associated with P. gingivalis infection.
本报告的目的是研究在小鼠脓肿模型中注射牙龈卟啉单胞菌后T淋巴细胞的作用。将三种侵袭性牙龈卟啉单胞菌分离株（ATCC 53977、W83和AJW4）注射到无胸腺BALB/c小鼠及其杂合子（nu/+）同窝小鼠体内。无胸腺BALB/c（nu/nu）小鼠能够将侵袭性牙龈卟啉单胞菌分离株定位在注射部位。相比之下，杂合子BALB/c（nu/+）同窝小鼠在皮下注射相同的侵袭性牙龈卟啉单胞菌分离株后24小时内出现出血性继发性病变。这些结果表明，初始T淋巴细胞可能与牙龈卟啉单胞菌感染相关的病理过程有关。
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