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用依赖T细胞生长因子的沙门氏菌特异性T细胞系将小鼠宿主对沙门氏菌病的保护进行过继转移。

Adoptive transfer of murine host protection to salmonellosis with T-cell growth factor-dependent, Salmonella-specific T-cell lines.

作者信息

Paul C, Shalala K, Warren R, Smith R

出版信息

Infect Immun. 1985 Apr;48(1):40-3. doi: 10.1128/iai.48.1.40-43.1985.

Abstract

A spent medium antigen was prepared from the avirulent RIA strain of Salmonella typhimurium. Lymph node cells isolated from female BALB/c mice injected subcutaneously with the spent medium antigen exhibited antigen-specific proliferation. By using these cells and T-cell growth factor, continuous spent medium antigen-specific, Thy 1.2-sensitive lines were generated. These cells exhibited antigen-specific proliferation in vitro and were effective in inducing significant (P less than 0.01) host protection when adoptively transferred to naive syngeneic mice.

摘要

一种用过的培养基抗原是由鼠伤寒沙门氏菌无毒RIA菌株制备的。从皮下注射用过的培养基抗原的雌性BALB/c小鼠分离的淋巴结细胞表现出抗原特异性增殖。通过使用这些细胞和T细胞生长因子,产生了连续的用过的培养基抗原特异性、Thy 1.2敏感细胞系。这些细胞在体外表现出抗原特异性增殖,当将其过继转移到同基因的未致敏小鼠时,能有效诱导显著的(P小于0.01)宿主保护。

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引用本文的文献

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Pathogenesis and immunity in murine salmonellosis.鼠伤寒沙门氏菌病的发病机制与免疫
Microbiol Rev. 1989 Dec;53(4):390-409. doi: 10.1128/mr.53.4.390-409.1989.

本文引用的文献

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Immunity to enteric infection in mice.肠道感染的免疫耐受。
Infect Immun. 1970 Mar;1(3):243-50. doi: 10.1128/iai.1.3.243-250.1970.
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