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与下丘脑肿瘤相关的性早熟。性激素治疗的效果。

Sexual precocity associated with a hypothalamic tumour. Effects of sex hormone therapy.

作者信息

David R, Rawlinson J, Ferguson K M

出版信息

Arch Dis Child. 1975 Feb;50(2):157-60. doi: 10.1136/adc.50.2.157.

DOI:10.1136/adc.50.2.157
PMID:165785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1544398/
Abstract

A case of sexual precocity of unusually early onset and associated with a hypothalamic tumour is described. The effects of ethinyl oestradiol and medroxyprogesterone acetate treatment have been monitored by plasma testosterone, FSH, and LH estimations. The results suggested a partial suppression of the tumour's influence, the mechanism of which is discussed.

摘要

本文描述了一例起病异常早且与下丘脑肿瘤相关的性早熟病例。通过检测血浆睾酮、促卵泡激素(FSH)和促黄体生成素(LH),监测了炔雌醇和醋酸甲羟孕酮治疗的效果。结果提示肿瘤的影响得到了部分抑制,并对其机制进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3fe/1544398/40cfd094c97d/archdisch00844-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3fe/1544398/40cfd094c97d/archdisch00844-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d3fe/1544398/40cfd094c97d/archdisch00844-0082-a.jpg

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Sexual precocity associated with a hypothalamic tumour. Effects of sex hormone therapy.与下丘脑肿瘤相关的性早熟。性激素治疗的效果。
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本文引用的文献

1
A clinical routine-method for the quantitative determination of gonadotrophins in 24-hour urine samples.一种用于定量测定24小时尿液样本中促性腺激素的临床常规方法。
Acta Endocrinol (Copenh). 1958 May;28(1):69-88. doi: 10.1530/acta.0.0280069.
2
Effect of several estrogens on serum gonadotropin levels in postmenopausal women.几种雌激素对绝经后妇女血清促性腺激素水平的影响。
Horm Metab Res. 1972 Jul;4(4):288-92. doi: 10.1055/s-0028-1094069.
3
Regulation of human gonadotropins. XII. Increase in serum gonadotropins in response to estradiol.
人促性腺激素的调节。十二。雌二醇刺激下血清促性腺激素水平的升高。
J Clin Endocrinol Metab. 1972 Feb;34(2):342-7. doi: 10.1210/jcem-34-2-342.
4
Suppression of urinary and plasma follicle-stimulating hormone by exogenous estrogens in prepubertal and pubertal children.外源性雌激素对青春期前及青春期儿童尿液和血浆中促卵泡激素的抑制作用。
J Clin Invest. 1973 May;52(5):1122-8. doi: 10.1172/JCI107278.
5
Radioimmunoassay of plasma testosterone.血浆睾酮的放射免疫测定
J Steroid Biochem. 1972 Apr;3(3):333-48. doi: 10.1016/0022-4731(72)90080-5.
6
Gonadotropin suppression by low dose estrogen in men: evidence for differential effects upon FSH and LH.低剂量雌激素对男性促性腺激素的抑制作用:对促卵泡生成素和促黄体生成素的不同影响的证据。
J Clin Endocrinol Metab. 1972 Dec;35(6):836-9. doi: 10.1210/jcem-35-6-836.
7
A critical appraisal of a method fo estimating urinary 17-oxosteroids and total 17-oxogenic steroids. A memorandum prepared at the request of the clinical Endocrinology Committee of the Medical Research Council.对一种估算尿中17-氧类固醇和总17-生氧类固醇方法的批判性评价。应医学研究理事会临床内分泌学委员会要求编写的一份备忘录。
Lancet. 1969 Jan 18;1(7586):124-7. doi: 10.1016/s0140-6736(69)91137-4.