[Lack of antidepresant-like activity of some ligands of polyamine binding sites of NMDA receptors in models of depression].

Arcain and a series of the partial modulators of polyamine binding sites of NMDA receptors (spermine- and adamantyl-containing polyamines IEM-1460, IEM-1490, IEM-1592, IEM-1755) do not display (in contrast to melipramine and memantine) antidepressant-like action in the forced swimming test and reserpine-induced depression test in rats. Compounds IEM-1460, IEM-1490, IEM-1592 increase the total time of immobilization in the Porsolt test, probably, by facilitating the development of stress-induced depression. It is supposed that the prodepressant activity of these compounds is mediated by NMDA-receptors having NR1/NR2C and NR1/NR2D subunit composition.