[NMDA 受体“快速”阻滞剂与多胺的抗遗忘特性比较]

[Comparison of anti-amnesia properties of NMDA-receptor "fast" blockers and polyamines].

作者信息

Gmiro V E, Zhuravskiĭ A V, Komissarov I V, Tikhonov V N

机构信息

Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, Kamennoostrovskii pr. 69/71, St. Petersburg, 197022 Russia.

出版信息

Eksp Klin Farmakol. 2002 Jan-Feb;65(1):11-4.

PMID:12025775

Abstract

The experiments on rats showed that IEM-1460, IEM-1490, and IEM-1755 (bisammonium adamantyl-containing compounds possessing fast NMDA channel blocking activity) and polyamines (spermine and arcain) do not alter acquiring of the passive avoidance reaction. All these compounds improve, albeit with different efficacy, the memory traces impaired by scopolamine and/or electroshock: IEM-1755 eliminated amnesia induced by the electroshock, but enhanced the amnesia evoked by scopolamine. Arcain inhibited (for a short time and in a narrow dose range) the antiamnesic effect of IEM-1460. It is suggested that the antiamnesic effect of compounds from both groups is related to the ability of slowing down the NMDA receptor desensitization.

摘要

对大鼠的实验表明，IEM - 1460、IEM - 1490和IEM - 1755（含金刚烷基的双铵化合物，具有快速的NMDA通道阻断活性）以及多胺（精胺和肌肽）不会改变被动回避反应的习得。所有这些化合物尽管功效不同，但都能改善由东莨菪碱和/或电击损伤的记忆痕迹：IEM - 1755消除了电击诱导的失忆，但增强了东莨菪碱引起的失忆。肌肽抑制（在短时间内且在狭窄剂量范围内）IEM - 1460的抗失忆作用。有人认为，两组化合物的抗失忆作用都与减缓NMDA受体脱敏的能力有关。