Vogel G W
Arch Gen Psychiatry. 1975 Jun;32(6):749-61. doi: 10.1001/archpsyc.1975.01760240077006.
Studies on the behavioral consequences of rapid eye movement (REM) sleep deprivation in animals and humans are critically reviewed. In animals, converging evidence--some reasonably well controlled--indicates that REM sleep deprivation probably heightens central neural excitability and increased motivational behavior, but has nuclear or inconclusive effects on learning. In humans, evidence indicates that REM sleep deprivation is not dream deprivation and is not harmful to schizophrenic, depressed, or healthy subjects. Controversy continues about whether or not (some) schizophrenic patients respond abnormally to REM sleep deprivation by having no REM rebound. Controlled but unconfirmed work indicates that that endogenous, but not reactive, depressive patients are improved by REM sleep deprivation, a finding consistent with the animal behavioral consequences of the procedure and with the unique REM-depriving properties of efficacious antidepressant drugs.
对动物和人类快速眼动（REM）睡眠剥夺的行为后果的研究进行了批判性综述。在动物中，越来越多的证据——有些是经过合理良好控制的——表明REM睡眠剥夺可能会提高中枢神经兴奋性并增加动机行为，但对学习有核心或不确定的影响。在人类中，证据表明REM睡眠剥夺不是梦剥夺，对精神分裂症患者、抑郁症患者或健康受试者无害。关于（某些）精神分裂症患者是否因没有REM反弹而对REM睡眠剥夺有异常反应，争议仍在继续。有对照但未经证实的研究表明，内源性而非反应性抑郁症患者通过REM睡眠剥夺得到改善，这一发现与该过程对动物行为的影响以及有效抗抑郁药物独特的REM剥夺特性相一致。
