Dissous Colette, Khayath Naji, Vicogne Jérôme, Capron Monique
Unité Inserm 547, Institut Pasteur de Lille, 1 Rue du Pr. Calmette, 59019 Lille Cedex, France.
FEBS Lett. 2006 May 22;580(12):2968-75. doi: 10.1016/j.febslet.2006.03.046. Epub 2006 Mar 24.
Parasitic helminths remain major pathogens of both humans and animals throughout the world. The success of helminth infections depends on the capacity of the parasite to counteract host immune responses but also to exploit host-derived signal molecules for its development. Recent progress has been made in the characterization of growth factor receptors of various nematode and flatworm parasites with the demonstration that transforming growth factor beta (TGF-beta), epidermal growth factor (EGF) and insulin receptor signalling pathways are conserved in helminth parasites and potentially implicated in the host-parasite molecular dialogue and parasite development.
寄生性蠕虫仍然是全世界人类和动物的主要病原体。蠕虫感染的成功与否取决于寄生虫对抗宿主免疫反应的能力,也取决于利用宿主来源的信号分子进行自身发育的能力。最近在各种线虫和扁虫寄生虫的生长因子受体表征方面取得了进展,证明转化生长因子β(TGF-β)、表皮生长因子(EGF)和胰岛素受体信号通路在蠕虫寄生虫中是保守的,并且可能参与宿主-寄生虫分子对话和寄生虫发育。