孕32⁰/₇至34⁶/₇周早产女性的宫缩抑制：一项随机对照试验性研究
Tocolysis in women with preterm labor between 32 0/7 and 34 6/7 weeks of gestation: a randomized controlled pilot study.
作者信息
How Helen Y, Zafaranchi Leila, Stella Caroline L, Recht Katherine, Maxwell Rose A, Sibai Baha M, Spinnato Joseph A
机构信息
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, USA.
出版信息
Am J Obstet Gynecol. 2006 Apr;194(4):976-81. doi: 10.1016/j.ajog.2006.02.030.
OBJECTIVE
The purpose of this study was to determine whether intravenous magnesium sulfate (MgSO4) followed by oral nifidepine tocolysis in women with preterm labor between 32 0/7 and 34 6/7 weeks' gestation reduces neonatal hospital stay.
STUDY DESIGN
Fifty-four women between 32 0/7 and 34 6/7 weeks with preterm labor were randomized to receive either MgSO4 and oral nifidepine (n = 24) or no tocolysis (n = 30). All women received betamethasone and prophylactic antibiotics. The primary outcome was total neonatal hospital stay. Data were analyzed using Chi-square and Mann Whitney U test.
RESULTS
The 2 groups had similar mean cervical dilation and gestational age at enrollment. There were no statistically significant differences in total neonatal hospital stay (5.8 +/- 7.2 days; median of 3 days in the no tocolysis vs. 7.5 +/- 8.6 days; median of 3 days in the tocolysis group), rate of preterm delivery (57% vs. 75%) or need for oxygen supplementation (7% vs. 21%, p < 0.23). The neonatal complications were similar in each group.
CONCLUSION
Tocolysis after 32 weeks gestation does not reduce neonatal hospital stay.
目的
本研究旨在确定妊娠32⁰/₇至34⁶/₇周早产的女性静脉注射硫酸镁（MgSO₄）后口服硝苯地平进行安胎治疗是否能缩短新生儿住院时间。
研究设计
54例妊娠32⁰/₇至34⁶/₇周早产的女性被随机分为两组，分别接受硫酸镁和口服硝苯地平治疗（n = 24）或不进行安胎治疗（n = 30）。所有女性均接受倍他米松和预防性抗生素治疗。主要结局指标为新生儿总住院时间。采用卡方检验和曼-惠特尼U检验对数据进行分析。
结果
两组入组时的平均宫颈扩张程度和孕周相似。新生儿总住院时间（未进行安胎治疗组为5.8±7.2天，中位数为3天；安胎治疗组为7.5±8.6天，中位数为3天）、早产率（57%对75%）或吸氧需求（7%对21%，p<0.23）方面均无统计学显著差异。两组的新生儿并发症相似。
结论
妊娠32周后进行安胎治疗并不能缩短新生儿住院时间。
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