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伴有肌原纤维聚集体的非典型性肌病

Atypical myopathy with myofibrillar aggregates.

作者信息

Kinoshita M, Satoyoshi E, Suzuki Y

出版信息

Arch Neurol. 1975 Jun;32(6):417-20. doi: 10.1001/archneur.1975.00490480083010.

DOI:10.1001/archneur.1975.00490480083010
PMID:165803
Abstract

An autopsy of a 23-year-old woman with progressive muscular weakness and wasting showed a unique muscle abnormality with segmental involvement of individual fibers by peculiar inclusions. Electron microscopically, these inclusions resembled cytoplasmic bodies, being formed of two concentric zones of filamentous materials. They seemed to arise from filaments of myofibrils that were fragmented and highly disorganized in affected areas.

摘要

对一名患有进行性肌肉无力和消瘦的23岁女性进行的尸检显示,其肌肉存在独特异常,个别纤维呈节段性受累,并伴有特殊包涵体。电子显微镜下,这些包涵体类似胞质体,由丝状物质的两个同心区域构成。它们似乎源自肌原纤维的细丝,在受影响区域这些细丝破碎且高度紊乱。

相似文献

1
Atypical myopathy with myofibrillar aggregates.伴有肌原纤维聚集体的非典型性肌病
Arch Neurol. 1975 Jun;32(6):417-20. doi: 10.1001/archneur.1975.00490480083010.
2
A primary bovine skeletal myopathy with absence of Z discs, sarcoplasmic inclusions, myofibrillar hypoplasia and nuclear abnormality.一种原发性牛骨骼肌病,伴有Z线缺失、肌浆内包涵体、肌原纤维发育不全和核异常。
J Comp Pathol. 1979 Jul;89(3):381-8. doi: 10.1016/0021-9975(79)90028-8.
3
Slowly progressive congenital myopathy with cytoplasmic bodies--report of two cases and a review of the literature.
Clin Neuropathol. 1982;1(2):55-66.
4
Hyaline body myopathy.透明体肌病
Neuromuscul Disord. 1994 May;4(3):257-62. doi: 10.1016/0960-8966(94)90027-2.
5
Intranuclear and cytoplasmic filamentous inclusions in distal myopathy (Welander).远端型肌病(韦兰德型)中的核内和胞质丝状包涵体
Acta Neuropathol. 1991;82(2):102-6. doi: 10.1007/BF00293951.
6
Morphology of acute myopathy associated with influenza B infection.与乙型流感感染相关的急性肌病的形态学
Pediatr Pathol. 1983 Jan-Mar;1(1):51-66. doi: 10.3109/15513818309048284.
7
Idiopathic cardiomyopathy and skeletal muscle abnormality.特发性心肌病和骨骼肌异常。
Am Heart J. 1975 Dec;90(6):767-73. doi: 10.1016/0002-8703(75)90467-6.
8
Basophilic inclusions in skeletal muscle from two cases of hypothyroid myopathy.两例甲状腺功能减退性肌病患者骨骼肌中的嗜碱性包涵体。
Acta Neuropathol Suppl. 1981;7:320-2. doi: 10.1007/978-3-642-81553-9_92.
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Follow-up studies in a case of unusual congenital myopathy, suggestive of nemaline type.对一例不寻常的先天性肌病(提示为杆状体肌病类型)的随访研究。
Acta Neuropathol. 1992;83(4):371-8. doi: 10.1007/BF00713528.
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Myofibrillar myopathy with abnormal foci of desmin positivity. I. Light and electron microscopy analysis of 10 cases.伴有结蛋白阳性异常病灶的肌原纤维肌病。I. 10例病例的光镜和电镜分析
J Neuropathol Exp Neurol. 1996 May;55(5):549-62. doi: 10.1097/00005072-199605000-00008.

引用本文的文献

1
Myofibrillar myopathy: towards a mechanism-based definition as a Z-disk-opathy.肌原纤维肌病:迈向基于机制的定义,即作为一种Z盘病。
Curr Opin Neurol. 2025 Jun 10. doi: 10.1097/WCO.0000000000001397.
2
Titin founder mutation is a common cause of myofibrillar myopathy with early respiratory failure.titin 基因突变是导致伴有早期呼吸衰竭的肌原纤维肌病的常见原因。
J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):331-8. doi: 10.1136/jnnp-2012-304728. Epub 2013 Mar 13.
3
Titin mutation segregates with hereditary myopathy with early respiratory failure.
肌联蛋白突变与遗传性肌病伴早期呼吸衰竭相关。
Brain. 2012 Jun;135(Pt 6):1695-713. doi: 10.1093/brain/aws102. Epub 2012 May 9.
4
Desmin and actin associated with cytoplasmic bodies in skeletal muscle fibers: immunocytochemical and fine structural studies, with a note on unusual 18- to 20-nm filaments.
Acta Neuropathol. 1990;80(4):406-14. doi: 10.1007/BF00307695.