Darke Shane, Williamson Anna, Ross Joanne, Teesson Maree
National Drug and Alcohol Research Centre, University of New South Wales, Australia.
Drug Alcohol Depend. 2006 Sep 15;84(2):201-5. doi: 10.1016/j.drugalcdep.2006.03.004. Epub 2006 Apr 3.
To determine whether reductions in frequency of heroin use were associated with reductions in the use of other drugs over a 24-month period.
Longitudinal cohort, with follow-up at 3, 12 and 24 months.
Six hundred and fifteen heroin users recruited for the Australian Treatment Outcome Study.
New South Wales, Australia.
The proportion reporting weekly heroin use declined significantly at 3, 12 and 24 months. Reductions in heroin use were associated with longer periods in both residential rehabilitation (RR) and maintenance treatment (MT). Less frequent use of other opioids, cocaine, amphetamine, cannabis and benzodiazepines were noted over follow-up, with alcohol use remaining stable. Across follow-up, lower frequency heroin use was associated with reduced likelihood of frequent use of other opioids, cocaine, amphetamine and benzodiazepines. Alcohol and cannabis use were unrelated to heroin use. Longer periods spent in RR were associated with declines in the use of all other drug classes, with MT associated with declines in other opioid and alcohol use.
There was no evidence for drug substitution in the face of reduced heroin use in this cohort of treatment seekers. The fear that a successful reduction in heroin use amongst treatment seekers will precipitate an increase in the use of other drugs appears ill-founded.
确定在24个月期间海洛因使用频率的降低是否与其他药物使用的减少相关。
纵向队列研究,在3个月、12个月和24个月时进行随访。
为澳大利亚治疗结果研究招募的615名海洛因使用者。
澳大利亚新南威尔士州。
报告每周使用海洛因的比例在3个月、12个月和24个月时显著下降。海洛因使用的减少与住院康复(RR)和维持治疗(MT)的时间延长有关。在随访期间,其他阿片类药物、可卡因、苯丙胺、大麻和苯二氮卓类药物的使用频率降低,而酒精使用保持稳定。在整个随访过程中,较低频率的海洛因使用与频繁使用其他阿片类药物、可卡因、苯丙胺和苯二氮卓类药物的可能性降低有关。酒精和大麻的使用与海洛因使用无关。在RR中花费的时间越长,与所有其他药物类别的使用下降有关,MT与其他阿片类药物和酒精使用的下降有关。
在这一寻求治疗的人群中,没有证据表明在海洛因使用减少的情况下存在药物替代现象。担心寻求治疗者中成功减少海洛因使用会导致其他药物使用增加似乎没有根据。