自身免疫性疾病和炎症性疾病中的细胞表面及细胞因子生物标志物

Cell-surface and cytokine biomarkers in autoimmune and inflammatory diseases.

作者信息

O'Hara Richard M, Benoit Stephen E, Groves Christopher J, Collins Mary

机构信息

Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA.

出版信息

Drug Discov Today. 2006 Apr;11(7-8):342-7. doi: 10.1016/j.drudis.2006.02.009.

DOI:10.1016/j.drudis.2006.02.009

PMID:16580976

Abstract

Increasing emphasis is being placed on biomarkers as indicators of disease states in patients with autoimmune and inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. Careful description of the expression of cell-surface markers and cytokines produced by T and B lymphocytes can lead to a more complete characterization of disease activity in patient populations, and serve as an indicator of the patient's response to therapy.

摘要

在自身免疫性和炎性疾病患者中，生物标志物作为疾病状态指标正受到越来越多的重视，这些疾病包括类风湿性关节炎、多发性硬化症和系统性红斑狼疮。仔细描述T和B淋巴细胞产生的细胞表面标志物和细胞因子的表达情况，有助于更全面地表征患者群体的疾病活动，并作为患者对治疗反应的指标。