Griesinger F, Jansen B, Kersey J H
Department of Laboratory Medicine/Pathology, University of Minnesota, Minneapolis 55455.
J Immunol. 1991 Nov 15;147(10):3336-41.
Mechanisms for the unstable and reversible differentiation of a mature CD3+ CD7+TCR-alpha/beta+ T lymphoid leukemia into the myeloid lineage were investigated. Inasmuch as productive rearrangement of the TCR-alpha is a late determinant of T cell differentiation, the TCR-alpha rearrangement was sequenced to determine the state of differentiation of the leukemic multipotent cell. An identical productive rearrangement of J alpha C to a novel V alpha region was found in the myeloid and T lymphoid leukemic cells. Thus, a "terminally" differentiated T lymphoid leukemic cell after productively rearranging TCR-alpha and -beta continues to display potential for multilineage differentiation. Therefore, multilineage potential is due to an unstable and reversible differentiation in a mature T lymphocyte as opposed to differentiation of an uncommitted common T and myeloid precursor cell.
研究了成熟的CD3 + CD7 + TCR-α/β + T淋巴细胞白血病向髓系谱系不稳定且可逆分化的机制。由于TCR-α的有效重排是T细胞分化的晚期决定因素，对TCR-α重排进行测序以确定白血病多能细胞的分化状态。在髓系和T淋巴系白血病细胞中发现JαC与一个新的Vα区域发生了相同的有效重排。因此，在有效重排TCR-α和-β后，一个“终末”分化的T淋巴系白血病细胞仍显示出多谱系分化的潜力。所以，多谱系潜力是由于成熟T淋巴细胞中存在不稳定且可逆的分化，而不是未定向的常见T和髓系前体细胞的分化。
