Magide A A, Myant N B, Reichl D
Atherosclerosis. 1975 Mar-Apr;21(2):205-15. doi: 10.1016/0021-9150(75)90081-7.
The effect of nicotinic acid was investigated in Rhesus monkeys. Subcutaneous injections of nicotinic acid lower the plasma very low density lipoprotein (VVLDL) and low density lipoprotein (HDL) concentration. The fall in LDL concentration is not accompained by any change in the lipid or protein composition of either lipoprotein. Analysis by Sephadex gel chromatography and polyacrylamide-gel electrophoresis showed that the proteins of monkey VLDL and LDL are qualitatively similar to those of human VLDL and LDL, although there are differences in the proportions of the various proteins present in the two species. Subcutaneous injections of nicotinic acid diminish the maximum incorporation of 14C from [14C]threonine into VLDL and LDL apoproteins, but have no effect on incorporation into albumin or HDL apoprotein. Peak incorporations into the apo-B and apo-C of VLDL are diminished to about equal extents by nicotinic acid. Comparison of the amount of 14C lost from apo-B of VLDL after the peak of incorporation, with that gained by apo-B of LDL during the same period, suggests that some of the circulating apo-B of LDL IS DERIVED FROM SOURCES OTHER THAN CIRCULATING VLDL.
在恒河猴身上研究了烟酸的作用。皮下注射烟酸可降低血浆极低密度脂蛋白（VVLDL）和低密度脂蛋白（HDL）浓度。低密度脂蛋白浓度的下降并未伴随任何一种脂蛋白的脂质或蛋白质组成的变化。通过葡聚糖凝胶色谱法和聚丙烯酰胺凝胶电泳分析表明，猴极低密度脂蛋白和低密度脂蛋白的蛋白质在性质上与人极低密度脂蛋白和低密度脂蛋白的蛋白质相似，尽管两种物种中各种蛋白质的比例存在差异。皮下注射烟酸减少了[14C]苏氨酸中14C掺入极低密度脂蛋白和低密度脂蛋白载脂蛋白的最大量，但对掺入白蛋白或高密度脂蛋白载脂蛋白没有影响。烟酸使极低密度脂蛋白载脂蛋白B和载脂蛋白C的掺入峰值减少到大致相同的程度。比较掺入峰值后极低密度脂蛋白载脂蛋白B损失的14C量与同期低密度脂蛋白载脂蛋白B获得的14C量，表明一些循环中的低密度脂蛋白载脂蛋白B并非来自循环中的极低密度脂蛋白。
