Romagnano M A, Harshbarger R J, Hamill R W
Neurology Unit, Monroe Community Hospital, Rochester, New York 14620.
J Neurosci. 1991 Nov;11(11):3539-55. doi: 10.1523/JNEUROSCI.11-11-03539.1991.
The present studies in the rat employed a combined retrograde transport-immunocytochemical technique to determine the origin in the brainstem of enkephalin (Enk) projections to spinal sympathetic nuclei, including the intermediolateralis nucleus, pars principalis (ILp). We found that Enk projections to the ILp nucleus are found in such serotonergic-containing areas as the raphe obscurus; raphe pallidus; gigantocellular reticular nucleus, pars alpha; paragigantocellular lateral nucleus; raphe magnus; and the rostral extension of the raphe magnus nucleus. The adrenergic-containing rostroventrolateral reticular nucleus as well as the noradrenergic-containing areas A5, A7, ventral locus coeruleus, subcoeruleus, and fiber pathway linking the locus coeruleus and A5/A7 send Enk projections to ILp. In the pons, a large contralateral Enk projection to spinal sympathetic nuclei was found medial to the facial nerve and medial to the motor nucleus of the trigeminal nerve. These observations show the existence of a large number of Enk brainstem regions that can influence spinal autonomic centers via descending supraspinal projections.
目前在大鼠身上进行的研究采用了逆行运输-免疫细胞化学联合技术，以确定脑啡肽（Enk）投射到脊髓交感神经核（包括中间外侧核主部，即ILp）的脑干起源。我们发现，向ILp核的Enk投射存在于含5-羟色胺的区域，如中缝隐核、中缝苍白核、巨细胞网状核α部、旁巨细胞外侧核、中缝大核以及中缝大核的吻侧延伸部。含肾上腺素的吻侧腹外侧网状核以及含去甲肾上腺素的区域A5、A7、腹侧蓝斑、蓝斑下核，以及连接蓝斑和A5/A7的纤维通路都向ILp发送Enk投射。在脑桥中，在面神经内侧和三叉神经运动核内侧发现了一条向脊髓交感神经核的大的对侧Enk投射。这些观察结果表明，存在大量可通过下行脊髓上投射影响脊髓自主神经中枢的Enk脑干区域。
