Dubrovina N I, Popova N K, Gilinskii M A, Tomilenko R A, Seif I
State Science Research Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences.
Neurosci Behav Physiol. 2006 May;36(4):335-9. doi: 10.1007/s11055-006-0022-z.
We report here the results obtained from comparative analysis of learning and the dynamics of extinction of a conditioned passive avoidance response in mice with genetic knockout of monoamine oxidase A (MAO A) and the progenitor line C3H. Mice of both lines acquired the conditioned passive avoidance reaction efficiently. Mice with genetic knockout of MAO A were characterized by prolonged retention of reproduction of the memory trace, as compared with rapid extinction in C3H mice. Smaller numbers of transfers, and vertical rearings on days 7-13 and the numbers of glances into and rom the dark sector on days 11-13 of extinction in MAO A-knockout mice appear to reflect their more marked fear reactions when confronted with the "dangerous" sector, along with increased anxiety, these facilitating longer-lasting retention of the memory trace.
我们在此报告对单胺氧化酶A（MAO A）基因敲除小鼠和祖系C3H小鼠的学习及条件性被动回避反应消退动力学进行比较分析所获得的结果。两个品系的小鼠都能高效习得条件性被动回避反应。与C3H小鼠的快速消退相比，MAO A基因敲除小鼠的特点是记忆痕迹再现的保留时间延长。MAO A基因敲除小鼠在消退第7 - 13天的转移次数和垂直站立次数较少，以及在消退第11 - 13天进出黑暗区域的张望次数较少，这似乎反映出它们在面对“危险”区域时更明显的恐惧反应，同时焦虑增加，这些因素促进了记忆痕迹的更持久保留。
